Precision Biopharmaceutical QC with Capillary Electrophoresis at Scinai BioServices
Elevate your quality control of precision biopharmaceuticals with the power of Capillary Electrophoresis at Scinai BioServices
a fast, powerful, and precise tool for unlocking the potential of protein analysis.
At Scinai BioServices, Capillary Electrophoresis (CE) is more than an analytical technique - it’s a cornerstone of our commitment to precision, quality, and regulatory compliance in biopharmaceutical development. CE enables high-resolution separation and quantitative characterization of proteins, ensuring that every biologic we help develop meets the highest standards of safety and efficacy.
How Does Capillary Electrophoresis Work?
Capillary Electrophoresis separates molecules based on size and/or charge using a fused silica capillary and an applied electric field. Key principles include:
High voltage drives charged molecules through a buffer-filled capillary
Controlled buffer conditions maintain optimal pH and ionic strength for separation
High resolution, low sample volume, and rapid analysis
Automation and reproducibility surpass traditional gel electrophoresis
CE allows precise, quantitative separation of proteins, aggregates, fragments, and charge variants, providing a clear and reliable analytical readout.
Why Use Capillary Electrophoresis?
CE is widely trusted because it provides:
High-resolution separation for complex protein mixtures
Quantitative precision for reproducible results
Rapid, automated workflows that minimize human error
Low sample volume requirements, ideal for limited or costly biologics
Data-rich outputs that support DoE, formulation studies, and stability analysis
GMP compatibility for regulatory-compliant workflows
Its speed, precision, and automation make CE indispensable for modern biopharmaceutical QC.
Role in Biopharmaceutical QC at Scinai
At Scinai, CE is central to our quality control processes, supporting every stage of biologic development:
Purity assessment: Detect protein aggregates, fragments, and other impurities
Charge variant profiling: Ensure post-translational modifications and protein function remain consistent
Glycosylation characterization: Monitor critical quality attributes
Batch release testing: Generate regulatory-ready data aligned with ICH Q6B standards
Formulation and stability studies: Track protein integrity over time
By providing fast, reproducible, and precise measurements, CE ensures biologics are safe, effective, and compliant.
Scinai Uses Maurice for Integrated CE Analysis
We leverage the ProteinSimple Maurice System for CE workflows, which integrates:
CE-SDS: Size-based protein separation
CE-IEF: Charge-based protein separation
Maurice offers:
Pre-assembled cartridges and ready-to-use reagents
Standardized automated protocols for consistent results
High-throughput capability in GMP-compliant environments
Automated data analysis and reporting
This integration ensures reliable, reproducible, and regulatory-ready results across all batches, accelerating QC workflows without compromising quality.
CE at Scinai is a powerful, precise, and rapid tool that supports high-quality, regulatory-ready protein analysis, helping our partners bring innovative biologics to market faster and with confidence.
A Word from Limor Landsman, QC Expert
“At Scinai, Capillary Electrophoresis isn’t just a technique—it’s our commitment to precision. As a gold-standard method in biopharmaceutical development, CE drives the quality and accuracy of our work, ensuring every biologic we help develop is safe, effective, and consistent.”
Limor Landsman, QC Expert, Scinai BioServices
